Lionel Messi’s majestic display at the Nou Camp in the last round inspired Barcelona to victory against Chelsea. And the Argentine forward will be looking to strike again as he goes in search of a fifth Champions League title.
For Roma, their task is gain a result that will stand them in good stead as they welcome the Catalan Giants back to Rome in one weeks time for the second-leg.
Barcelona vs Roma: Who will win?
Barcelona are enormous 2/9 favourites to win.
Back Roma to claim a shock away win at massive 14/1 odds.
The draw is priced at 6/1.
Barcelona vs Roma preview
Barcelona have taken La Liga by storm this season, currently holding a nine-point advantage over Atletico Madrid and an emphatic 14 point lead over Real.
Messi and Luis Suarez combined on Saturday to produce a thrilling comeback against Sevilla, as the two South Americans netted twice within the space of just 54 seconds to maintain their unbeaten in the league this season.
Sat third in Serie A, Roma have enjoyed a successful campaign so far and have proven themseleves to be a side that should be taken seriously.
Having eliminated Atletico and beaten Chelsea, the Italian side have shown their quality to succeed in Europe, however, Wednesday promises to comfortably be their toughest test yet.
Striker Edin Dzeko has flourished since moving to Italy and having netted 18 goals in all competitions this season, Eusebio Di Francesco will be looking to the Bosnian for inspiration at the Nou Camp.
Leo Messi inspired the Catalan Giants to victory over Chelsea as he netted twice at Nou Camp to send his side into the quarter-finals of the Champions League.
Ousmane Dembele also netted on the night as Barcelona produced a rampant display to win 4-1 on aggregate against the reigning Premier League champions.
Roma would have been licking their lips at the prospect of facing Shakhtar Donetsk in the last-16 but following 180 minutes of football, the Italians just about stumbled over the line.
Edin Dzeko scored the only goal of the night in the second-leg and courtesy of Cengiz Under’s goal in Ukraine, Roma claimed the tie on away goals.
Barcelona team news vs Roma
Barcelona will be without Philippe Coutinho who is cup-tied having played in the competition for Liverpool.
Meanwhile, Sergio Busquets is expected to be fit to face the Italian side having returned to training this week.
Lucas Digne and Sergi Samper have both been ruled out due to injury.
Roma team news vs Barcelona
Attacker Cengiz Under is unlikely to make the trip to Spain because of injury.
Radja Nainggolan looks likely to overcome an injury to return on Wednesday.